The daughter of a slasher herself, Cassie wonders if that is part of the reason she kills. She worries if it is something so ingrained in her that she'll ever be able to quit. All of the slashers in the comic are done movie style, so most of them are able to return from the dead, including Cassie's mother (there is an explanation for that in the series, don't want to spoiler it for you).
There is a supernatural element to the series as well, as people make deals with the devil to gain success. Whenever a deal is made, the devil demands a "quota" of souls, meaning lives must be taken to maintain success. One of the most lovable characters in the series is actually a hell hound names Pooch who has been sent to earth to hunt Cassie, but finds his living accommodations with her friends too nice to do so.
Cassie is aided by Vlad, her protector, and gentle giant. Other people in Cassie's posse include Georgia, Cassie's best friend/sometimes girlfriend/stripper, and Lisa and Chris, whom Cassie saved from a slasher, and they now run Hack/Slash Inc., the website where people can go to report slashers and have Cassie look into the case.
It's super violent and kind of racy, but the story is truly entertaining. I devoured nearly two omnibuses last night, so you know it's good.